Is there a difference between sickle cell disorder, disease and anemia? 镰状细胞紊乱、镰状细胞病和镰状细胞性贫血之间有何差异?
Renal damage due to sickle cell anemia 镰状细胞贫血性肾损害
Seen here is the small remnant of spleen in a patient with sickle cell anemia. 如图可见镰状细胞贫血患者残存的小脾脏。
Likewise, in people with a genetic disorder such as sickle cell anemia, the new blood system would not have the sickle-cell mutation, eliminating the cause of disease. 同样的,对于遗传疾病(如镰状细胞性贫血)患者,新造血系统不再有镰状红细胞变异,因此消除了该疾病的病因。
These disorders may include cystic fibrosis, hemophilia, sickle cell anemia, and many others. 这些变异包括包囊纤维症、血友病、镰状细胞贫血症和其他多种疾病。
Additionally, the increase of fetal hemoglobin ( HbF, α_2 γ_2) can ameliorate the clinical symptoms of inherited abnormalities of β-globin gene expression, such as β-thalassemia and sickle cell anemia. 另外,胎儿血红蛋白(HbF,α2γ2)的升高能够减轻由于β-珠蛋白基因表达异常所致的遗传病(如β-地中海贫血和镰刀型细胞贫血)的临床症状。
The investigations of these natural mutants may contribute to elucidation of the mechanisms of hemoglobin switching as well as provide certain strategies for gene therapy of β-thalassemia and sickle cell anemia. 所以,对这些天然突变体的研究不仅有助于揭示血红蛋白开关机制,而且可能为β-地中海贫血和镰刀型细胞贫血的基因治疗提供线索。
Right ventricular abnormalities in sickle cell anemia: Evidence of a progressive increase in pulmonary vascular resistance 镰刀状红细胞贫血患儿的右心室异常改变:进展性肺循环血管阻力增高的临床证据
Effect of long-term transfusion on growth in children with sickle cell anemia: Results of the stop trial 长期输血对镰状细胞性贫血(SCA)儿童生长发育的影响:防治该病发作的试验结果
The reasons for a lots of human genetic diseases are related to the variation of nucleotide molecular base sequences, such as Patient fibrosis, Benzene acetone urine disease, Sickle cell anemia, hemophilia, tumor and so on. 人类的诸多遗传疾病都和核苷酸分子碱基序列变异有关,如包囊纤维变性、苯丙酮尿症、镰状红血球贫血症、血友病、肿瘤等。